Alpha-2-macroglobulin (A2M) is a blood protein that can bind certain enzymes involved in cartilage breakdown. At NexGenEsis Healthcare Honolulu, A2M injections are offered as a targeted, minimally invasive option for select patients with degenerative joint pain.

---

The Basic Idea

BA2M is concentrated using a specific protocol

The A2M-rich solution is injected into the affected joint (often the knee) under guidance

The aim is to neutralize cartilage-damaging enzymes and help protect remaining cartilage, potentially easing pain

Some patients report improved pain and function; others notice little change. It’s one tool among many, not a cure-all.

Who Might Be a Candidate

We may consider A2M injections if you:

• Have mild to moderate osteoarthritis
  
• Want to explore biologic options beyond standard steroids or hyaluronic acid
  
• Understand that benefits are not guaranteed and may be modest
  

We always position A2M in context with other options, not above them by default.
If you’re weighing different injection options for osteoarthritis in Honolulu, schedule a visit at NexGenEsis Healthcare to find out whether A2M belongs in your treatment strategy way to support pain relief and recovery in Honolulu.