Still fighting joint stiffness and swelling even after PT, NSAIDs, or cortisone?
When pain keeps creeping back but surgery feels premature, Alpha-2-Macroglobulin (A2M) injections at NexGenEsis Healthcare – Clearwater offer a targeted, non-surgical option.

What A2M is—and why it’s used

A2M is a large blood protein that binds cartilage-damaging enzymes (think MMPs/ADAMTS). By concentrating A2M and injecting it into the joint under image guidance, the goal is to reduce enzyme activity, help calm inflammatory cascades, and support the cartilage that remains.

Who it may help

• Mild-to-moderate osteoarthritis with swelling or recurring “flare-ups.”
• Patients who had short-lived relief from steroids or hyaluronic acid and want a biologic, enzyme-blocking approach.
• People aiming to delay or avoid surgery while improving daily function.

What to expect

• Visit flow: evaluation → image-guided injection → home the same day.
• Aftercare: brief soreness is common for 24–72 hours; activity ramps gradually.
• Timeline: responses vary—some notice change within weeks; others need a series or a combined plan.

How it fits with other options
We’ll compare A2M with PRP, BMAC, and traditional injections so you know exactly where A2M sits in your toolkit and when another route makes more sense (e.g., advanced instability or end-stage arthritis).

Safety notes
Typical injection risks (temporary pain, bruising, rare infection). We’ll review your history and imaging before recommending any procedure.

Take the first step
If arthritis pain is cutting into daily life in Clearwater, reach out to NexGenEsis Healthcare to see whether A2M injections fit your plan.