Alpha-2-macroglobulin (A2M) is a naturally occurring blood protein that can bind certain enzymes involved in cartilage breakdown. At NexGenEsis Healthcare Columbus, we offer A2M injections as a targeted, minimally invasive option for select patients with degenerative joint pain.

How A2M Therapy Works

• A sample of your blood is processed to concentrate A2M (depending on the protocol used).
  
• The A2M-rich solution is then injected into the affected joint (commonly the knee) under guidance.
  
• The intent is to neutralize cartilage-damaging enzymes, potentially slowing degenerative processes and easing symptoms.
  

Who Might Be a Candidate in Columbus

We may consider A2M injections if you:

• Have mild to moderate osteoarthritis with persistent pain
  
• Are not ready for or not interested in surgery
  
• Want to explore biologic options beyond standard steroid or hyaluronic acid injections
  
• Understand that benefit is not guaranteed and may be modest
  

A2M is usually not a first-line intervention and is always framed as one piece of the puzzle.

Realistic Expectations

• Some patients report meaningful pain relief and better function; others notice little change.
  
• Effects, if present, are usually evaluated over weeks to months, not days.
  
• We compare A2M honestly with PRP, BMAC, and traditional injections so you understand pros, cons, and cost for each.
  

If you’re in Columbus and reviewing injection options for arthritis pain, call NexGenEsis Healthcare to schedule an appointment and see whether A2M therapy makes sense for your case.treatments, contact NexGenEsis Healthcare Columbus to ask whether shockwave therapy could be part of your recovery plan.